Article
Assessing the potential of an induced-mutation strategy for avermectin overproducers.
Applied and environmental microbiology - 1 Jul 2010
Gao Hong, Liu Mei, Zhuo Ying, Zhou Xianlong, Liu Jintao, Chen Difei, Zhang Wenquan, Gou Zhongxuan, Shang Peng, Zhang Lixin
Abstract excerpt
Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and...
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