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Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.

Metabolic engineering - 1 Jan 2005

Stutzman-Engwall Kim, Conlon Steve, Fedechko Ronald, McArthur Hamish, Pekrun Katja, Chen Yan, Jenne Stephane, La Charlene, Trinh Na, Kim Seran, Zhang Ying-Xin, Fox Richard, Gustafsson Claes, Krebber Anke

Abstract excerpt

The avermectin analog doramectin (CHC-B1), sold commercially as Dectomax, is biosynthesized by Streptomyces avermitilis. aveC, a gene encoding an unknown mechanistic function, plays an essential role in the production of doramectin (avermectin CHC-B1), modulating the production ratio of CHC-B1 to other avermectins, most notably the undesirable analog CHC-B2. To improve the production ratio for doramectin, the...

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PMID: 15721808
DOI: 10.1016/j.ymben.2004.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semi-synthetic DNA shuffling of aveC leads to improved industrial scale production of doramectin by Streptomyces avermitilis.PMID 15721808Read ↗

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