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Article

PPM1D/Wip1 is amplified, overexpressed, and mutated in human non-Hodgkin's lymphomas.

Molecular biology reports - 4 Nov 2024

Pilevneli Hatice, Döger Firuzan, Karagenç Levent, Kozacı Didem, Kilic Eren Mehtap

Abstract excerpt

BACKGROUND: Wip1, is a p53-dependent Ser/Thr phosphatase involved in the timely termination of DDR. The PPM1D gene encoding Wip1 is deregulated and thus gained an oncogene character in common human solid tumors and cell lines. This study assessed the oncogenic potential of the PPM1D gene in human non- Hodgkin's lymphomas (NHL), the most common hematological malignancy worldwide. METHODS AND RESULTS: FFPE human...

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Share to Cytoskeletal Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Gene Expression Regulation, Neoplastic

Share to Intracellular Signaling Peptides and Proteins

Share to Lymphoma, Non-Hodgkin

Share to Protein Phosphatase 2C

Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 39489796
DOI: 10.1007/s11033-024-10029-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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