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Article

The role of PPM1D in cancer and advances in studies of its inhibitors

29 Jan 2020

Abstract excerpt

A greater understanding of factors causing cancer initiation, progression and evolution is of paramount importance. Among them, the serine/threonine phosphatase PPM1D, also referred to as wild-type p53-induced phosphatase 1 (Wip1) or protein phosphatase 2C delta (PP2Cδ), is emerging as an important oncoprotein due to its negative regulation on a number of crucial cancer suppressor pathways. Initially identified...

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PMID: 32006900
DOI: 10.1016/j.biopha.2020.109956

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