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Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

1 Mar 2015

Abstract excerpt

BACKGROUND: PPM1D (WIP1) negatively regulates by dephosphorylation many proteins including p53 tumour suppressor. The truncating mutations (nonsense and frameshift) in exon 6 of PPM1D were found recently in blood cells of patients with breast, ovarian or colorectal cancer. These mutants code for gain-of-function PPM1D with retained phosphatase activity. Their significance in carcinogenesis is unknown. METHODS:...

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PMID: 25742468
DOI: 10.1038/bjc.2015.79

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