Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

Molecular carcinogenesis - 1 Aug 2006

Nannenga Bonnie, Lu Xiongbin, Dumble Melissa, Van Maanen Marc, Nguyen Thuy-Ai, Sutton Richard, Kumar T Rajendra, Donehower Lawrence A

Abstract excerpt

The p53-induced serine/threonine phosphatase, protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D) (or wild-type p53-induced phosphatase 1 (Wip1)), exhibits oncogenic activity in vitro and in vivo. It behaves as an oncogene in rodent fibroblast transformation assays and is amplified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Checkpoint Kinase 1
Share to Checkpoint Kinase 2
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longevity

Share to p38 Mitogen-Activated Protein Kinases

Share to Phosphoprotein Phosphatases

Share to Protein Phosphatase 1

Share to Protein Phosphatase 2C

Source

Identifiers

PMID: 16652371
DOI: 10.1002/mc.20195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16652371-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.PMID 16652371Read ↗

Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.Semantic proximity Read ↗

The role of PPM1D in cancer and advances in studies of its inhibitorsSemantic proximity Read ↗

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.Semantic proximity Read ↗

Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon.Semantic proximity Read ↗

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sitesSemantic proximity Read ↗

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.Semantic proximity Read ↗

Ppm1d truncating mutations promote the development of genotoxic stress-induced AML.Semantic proximity Read ↗

Genetic variants and mutations of PPM1D control the response to DNA damage.Semantic proximity Read ↗

PPM1D in Solid and Hematologic Malignancies: Friend and Foe?Semantic proximity Read ↗

PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression.Semantic proximity Read ↗

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.Semantic proximity Read ↗

Regulation of the Wip1 phosphatase and its effects on the stress response Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J. Mazur, Ettore Appella, Albert J. Fornace Jr.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.