Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human natural killer cells exhibit negative regulatory function by ectopic expression of hFoxp3 gene.

Transplantation - 15 Jun 2013

Wang Fei, Jiang Wen, Zhang Cai, Tian Zhigang, Zhang Jian

Abstract excerpt

BACKGROUND: Foxp3 is a key marker of CD4CD25 regulatory T cells and appears highly specific for regulatory T cells. Human dendritic cells transfected with foxp3 gene also exhibit immunosuppressive functions. We want to understand whether natural killer (NK) cells could be endowed with regulatory properties by transduction of Foxp3 gene. METHODS: A recombinant vector (pRV.GFP Foxp3) or control vector (pRV.GFP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Forkhead Transcription Factors
Share to Graft vs Host Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Interleukin-10

Share to Killer Cells, Natural

Share to Leukocytes, Mononuclear

Share to Mice, SCID

Source

Identifiers

PMID: 23644754
DOI: 10.1097/TP.0b013e318290b086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human natural killer cells exhibit negative regulatory function by ectopic expression of hFoxp3 gene.PMID 23644754Read ↗

Control of regulatory T cell development by the transcription factor Foxp3.Semantic proximity Read ↗

Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells.Semantic proximity Read ↗

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.Semantic proximity Read ↗

FOXP3+ regulatory T cells in the human immune system.Semantic proximity Read ↗

Is FOXP3 a bona fide marker for human regulatory T cells?Semantic proximity Read ↗

Non-canonical NFKB signaling endows suppressive function through FOXP3-dependent regulatory T cell programSemantic proximity Read ↗

Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells.Semantic proximity Read ↗

FOXP3 modifies the phenotypic and functional properties of regulatory T cells.Semantic proximity Read ↗

Subcellular localization of FOXP 3 in human regulatory and nonregulatory T cellsSemantic proximity Read ↗

FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.Semantic proximity Read ↗

Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells.Semantic proximity Read ↗

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.