Article
Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells.
International immunology - 1 Feb 2006
Chen Shuming, Ishii Naoto, Ine Shouji, Ikeda Syuichi, Fujimura Taku, Ndhlovu Lishomwa C, Soroosh Pejman, Tada Kohtaro, Harigae Hideo, Kameoka Junichi, Kasai Noriyuki, Sasaki Takeshi, Sugamura Kazuo
Abstract excerpt
Adult T cell leukemia (ATL) is an aggressive neoplastic disease, in which a quarter of the patients develop opportunistic infections due to cellular immunodeficiency. However, the underlying mechanism responsible for the immunosuppression has remained unclear. Recent studies have demonstrated that the leukemia cells from a subset of patients with ATL express Foxp3, a specific marker for CD25+CD4+ regulatory T...
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