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Article

FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2009

Torgerson Troy R, Genin Anna, Chen Chunxia, Zhang Mingce, Zhou Bin, Añover-Sombke Stephanie, Frank M Barton, Dozmorov Igor, Ocheltree Elizabeth, Kulmala Petri, Centola Michael, Ochs Hans D, Wells Andrew D, Cron Randy Q

Abstract excerpt

The forkhead DNA-binding protein FOXP3 is critical for the development and suppressive function of CD4(+)CD25(+) regulatory T cells (T(REG)), which play a key role in maintaining self-tolerance. Functionally, FOXP3 is capable of repressing transcription of cytokine genes regulated by NFAT. Variou...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19564342
DOI: 10.4049/jimmunol.0800216
PMCID: PMC2778477

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19564342-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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