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Article

Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.

European journal of immunology - 1 Apr 2011

Passerini Laura, Di Nunzio Sara, Gregori Silvia, Gambineri Eleonora, Cecconi Massimiliano, Seidel Markus G, Cazzola Giantonio, Perroni Lucia, Tommasini Alberto, Vignola Silvia, Guidi Luisa, Roncarolo Maria G, Bacchetta Rosa

Abstract excerpt

Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The relevance of other peripheral tolerance mechanisms, such as the presence and function of type 1 regulatory T (Tr1) cells,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21400500
DOI: 10.1002/eji.201040909
PMCID: PMC3107421

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.PMID 21400500Read ↗

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