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Article

Subcellular localization of FOXP 3 in human regulatory and nonregulatory T cells

1 Jun 2012

Abstract excerpt

The transcriptional regulator FOXP3 is an important determinant of regulatory T (Treg) cell development and function and is frequently used to quantitate Treg cells. However, FOXP3 is also expressed in recently activated conventional human T cells. Here, we investigated the FOXP3 expression patterns in Treg and activated T cells at a cellular level. Upon activation, human CD4(+) CD25(-) T cells expressed FOXP3...

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PMID: 22678915
DOI: 10.1002/eji.201141838

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