Article
Complementary Gli activity mediates early patterning of the mouse visual system.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2006
Furimsky Marosh, Wallace Valerie A
Abstract excerpt
The Sonic hedgehog (Shh) signaling pathway plays a key role in the development of the vertebrate central nervous system, including the eye. This pathway is mediated by the Gli transcription factors (Gli1, Gli2, and Gli3) that differentially activate and repress the expression of specific downstream target genes. In this study, we investigated the roles of the three vertebrate Glis in mediating midline Shh...
Topics
- Animals
- Body Patterning
- Eye
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- Kruppel-Like Transcription Factors
- Mice
- Mice, Neurologic Mutants
- Mutation
- Nerve Tissue Proteins
- Optic Nerve