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Article

Neuroimaging Measures as Endophenotypes in Alzheimer′s Disease

1 Jan 2011

Abstract excerpt

Late onset Alzheimer's disease (AD) is moderately to highly heritable. Apolipoprotein E allele ε4 (APOE4) has been replicated consistently as an AD risk factor over many studies, and recently confirmed variants in other genes such as CLU, CR1, and PICALM each increase the lifetime risk of AD. However, much of the heritability of AD remains unexplained. AD is a complex disease that is diagnosed largely through...

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PMID: 21547229
DOI: 10.4061/2011/490140

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