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Article

Impact of genetic variation in SORCS1 on memory retention.

PloS one - 1 Jan 2011

Reitz Christiane, Lee Joseph H, Rogers Robert S, Mayeux Richard

Abstract excerpt

OBJECTIVE: We previously reported that genetic variants in SORCS1 increase the risk of AD, that over-expression of SorCS1 reduces γ-secretase activity and Aβ levels, and that SorCS1 suppression increases γ-secretase processing of APP and Aβ levels. We now explored the effect of variation in SORCS1 on memory. METHODS: We explored associations between SORCS1-SNPs and memory retention in the NIA-LOAD case control...

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Identifiers

PMID: 22046233
DOI: 10.1371/journal.pone.0024588
PMCID: PMC3202519

Genes

SORCS1
APP

Provenance

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