Article
Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.
PLoS medicine - 1 Apr 2017
White Charles C, Yang Hyun-Sik, Yu Lei, Chibnik Lori B, Dawe Robert J, Yang Jingyun, Klein Hans-Ulrich, Felsky Daniel, Ramos-Miguel Alfredo, Arfanakis Konstantinos, Honer William G, Sperling Reisa A, Schneider Julie A, Bennett David A, De Jager Philip L
Abstract excerpt
INTRODUCTION: The molecular underpinnings of the dissociation of cognitive performance and neuropathological burden are poorly understood, and there are currently no known genetic or epigenetic determinants of the dissociation. METHODS AND FINDINGS: "Residual cognition" was quantified by regressing out the effects of cerebral pathologies and demographic characteristics on global cognitive performance proximate to...
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