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Progress and Challenges in the Biology of FNDC5 and Irisin

25 Jan 2021

Abstract excerpt

In 2002, a transmembrane protein-now known as FNDC5-was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a study in 2012 proposed that, in response to exercise, the ectodomain of skeletal muscle FNDC5 was cleaved, traveled to white adipose tissue, and induced browning. The wasted energy of this browning raised the possibility that this...

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PMID: 33493316
DOI: 10.1210/endrev/bnab003

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