Article
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity.
Obesity facts - 1 Jan 2020
da Fonseca Ana Carolina Proença, da Fonseca Guilherme Proença, Marchesini Bruna, Voigt Danielle Dutra, Campos Junior Mario, Zembrzuski Verônica Marques, Carneiro João Regis Ivar, Nogueira Neto José Firmino, Cabello Pedro Hernan, Cabello Giselda Maria Kalil
Abstract excerpt
BACKGROUND: Regular physical activity has an important role in energy expenditure and combats the development of obesity. During exercise, PPARGC1A is overexpressed, stimulating an increase of the expression of FNDC5. This protein is cleaved to release the hormone irisin, which activates a browning process in white adipose tissue through an increase in UCP1 expression. As a result, irisin leads to mitochondrial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.