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Article

Browning of white fat: does irisin play a role in humans?

29 Apr 2014

Abstract excerpt

The discovery of irisin as an exercise-regulated myokine inducing browning of WAT has gained interest as a potential new strategy to combat obesity and its associated disorders, such as type 2 diabetes. However, there are inconsistencies regarding the relevance of irisin in humans. The regulation of FNDC5 mRNA expression by exercise and contraction could not be reproduced by a number of human studies using...

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Share to Adipose Tissue and Metabolism
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PMID: 24781257
DOI: 10.1530/joe-14-0189

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Browning of white fat: does irisin play a role in humans?PMID 24781257Read ↗

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Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.Semantic proximity Read ↗

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