Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

doi:10.1210/jc.2017-00056

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Article

Fibronectin Type III Domain-Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

The Journal of clinical endocrinology and metabolism - 1 Aug 2017

Petta Salvatore, Valenti Luca, Svegliati-Baroni Gianluca, Ruscica Massimiliano, Pipitone Rosaria Maria, Dongiovanni Paola, Rychlicki Chiara, Ferri Nicola, Cammà Calogero, Fracanzani Anna Ludovica, Pierantonelli Irene, Di Marco Vito, Meroni Marica, Giordano Debora, Grimaudo Stefania, Maggioni Marco, Cabibi Daniela, Fargion Silvia, Craxì Antonio

Abstract excerpt

Context: Contrasting data have been reported on the role of irisin, a novel myokine encoded by the fibronectin type III domain-containing protein 5 (FNDC5) gene, in nonalcoholic fatty liver disease (NAFLD) pathogenesis. We tested in patients with suspected nonalcoholic steatohepatitis (NASH) the association of FNDC5 variants, hepatic expression, and circulating irisin with liver damage (F2 to F4 fibrosis as main...

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PMID: 28472477
DOI: 10.1210/jc.2017-00056

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FNDC5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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