FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs.

doi:10.1007/s11357-014-9733-1

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FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs.

Age (Dordrecht, Netherlands) - 1 Jan 2014

Sanchis-Gomar Fabian, Garatachea Nuria, He Zi-hong, Pareja-Galeano Helios, Fuku Noriyuki, Tian Ye, Arai Yasumichi, Abe Yukiko, Murakami Haruka, Miyachi Motohiko, Yvert Thomas, Santiago Catalina, Venturini Letizia, Fiuza-Luces Carmen, Santos-Lozano Alejandro, Rodríguez-Romo Gabriel, Ricevuti Giovanni, Hirose Nobuyoshi, Emanuele Enzo, Lucia Alejandro

Abstract excerpt

Irisin might play an important role in reducing the risk of obesity, insulin resistance, or several related diseases, and high irisin levels may contribute to successful aging. Thus, the irisin precursor (FNDC5) gene is a candidate to influence exceptional longevity (EL), i.e., being a centenarian. It has been recently shown that two single-nucleotide polymorphisms (SNPs) in the FNDC5 gene, rs16835198 and...

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PMID: 25427998
DOI: 10.1007/s11357-014-9733-1
PMCID: PMC4245403

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FNDC5

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FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs.PMID 25427998Read ↗

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