Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Jun 2013

Boeckmann Lars, Takahashi Yoshimitsu, Au Wei-Chun, Mishra Prashant K, Choy John S, Dawson Anthony R, Szeto May Y, Waybright Timothy J, Heger Christopher, McAndrew Christopher, Goldsmith Paul K, Veenstra Timothy D, Baker Richard E, Basrai Munira A

Abstract excerpt

The centromeric histone H3 variant (CenH3) is essential for chromosome segregation in eukaryotes. We identify posttranslational modifications of Saccharomyces cerevisiae CenH3, Cse4. Functional characterization of cse4 phosphorylation mutants shows growth and chromosome segregation defects when combined with kinetochore mutants okp1 and ame1. Using a phosphoserine-specific antibody, we show that the association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aurora Kinase B
Share to Aurora Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Centromere

Share to Chromatography, Liquid

Share to Chromosomal Proteins, Non-Histone

Share to Chromosome Segregation

Share to Kinetochores

Share to Tandem Mass Spectrometry

Source

Open in PubMed Open full text

Identifiers

PMID: 23637466
DOI: 10.1091/mbc.E12-12-0893
PMCID: PMC3681705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae.PMID 23637466Read ↗

Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization.Semantic proximity Read ↗

A role for CENP-A/Cse4 phosphorylation on serine 33 in deposition at the centromere.Semantic proximity Read ↗

Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast.Semantic proximity Read ↗

The overexpression of a Saccharomyces cerevisiae centromeric histone H3 variant mutant protein leads to a defect in kinetochore biorientation.Semantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.Semantic proximity Read ↗

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.Semantic proximity Read ↗

Histone H2A is required for normal centromere function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Analysis of primary structural determinants that distinguish the centromere-specific function of histone variant Cse4p from histone H3.Semantic proximity Read ↗

SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4.Semantic proximity Read ↗

The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.Semantic proximity Read ↗

The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.