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Article

Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans.

Diabetes - 1 Aug 2013

Jonsson Anna, Ladenvall Claes, Ahluwalia Tarunveer Singh, Kravic Jasmina, Krus Ulrika, Taneera Jalal, Isomaa Bo, Tuomi Tiinamaija, Renström Erik, Groop Leif, Lyssenko Valeriya

Abstract excerpt

Although meta-analyses of genome-wide association studies have identified >60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information on whether these variants also affect α-cell function. The aim of the current study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We studied 43 SNPs in 4,654...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 23557703
DOI: 10.2337/db12-1627
PMCID: PMC3717852

Genes

NOTCH2
TSPAN8
CRY2
HHEX
IGF1
KCNJ11
ZBED3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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