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Article

The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation.

Molecular cell - 9 May 2013

Ross Wilma, Vrentas Catherine E, Sanchez-Vazquez Patricia, Gaal Tamas, Gourse Richard L

Abstract excerpt

The global regulatory nucleotide ppGpp ("magic spot") regulates transcription from a large subset of Escherichia coli promoters, illustrating how small molecules can control gene expression promoter-specifically by interacting with RNA polymerase (RNAP) without binding to DNA. However, ppGpp's ta...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23623682
DOI: 10.1016/j.molcel.2013.03.021
PMCID: PMC3654024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23623682-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation.PMID 23623682Read ↗

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