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Article

Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-Site.

Molecular cell - 5 Apr 2018

Winther Kristoffer Skovbo, Roghanian Mohammad, Gerdes Kenn

Abstract excerpt

RelA/SpoT homologs (RSHs) are ubiquitous bacterial enzymes that synthesize and hydrolyze (p)ppGpp in response to environmental challenges. Bacteria cannot survive in hosts and produce infection without activating the (p)ppGpp-mediated stringent response, but it is not yet understood how the enzymatic activities of RSHs are controlled. Using UV crosslinking and deep sequencing, we show that Escherichia coli RelA...

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Identifiers

PMID: 29625042
DOI: 10.1016/j.molcel.2018.02.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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