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Article

Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription.

Cell - 6 Aug 2004

Perederina Anna, Svetlov Vladimir, Vassylyeva Marina N, Tahirov Tahir H, Yokoyama Shigeyuki, Artsimovitch Irina, Vassylyev Dmitry G

Abstract excerpt

Bacterial transcription is regulated by the alarmone ppGpp, which binds near the catalytic site of RNA polymerase (RNAP) and modulates its activity. We show that the DksA protein is a crucial component of ppGpp-dependent regulation. The 2.0 A resolution structure of Escherichia coli DksA reveals a globular domain and a coiled coil with two highly conserved Asp residues at its tip that is reminiscent of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15294156
DOI: 10.1016/j.cell.2004.06.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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