Article
Properties of Escherichia coli RNA polymerase from a strain devoid of the stringent response alarmone ppGpp.
Acta biochimica Polonica - 1 Jan 2008
Szalewska-Pałasz Agnieszka
Abstract excerpt
The stringent response alarmone guanosine tetraphosphate (ppGpp) affects transcription from many promoters. ppGpp binds directly to the transcription enzyme of Escherichia coli, RNA polymerase. Analysis of the crystal structure of RNA polymerase with ppGpp suggested that binding of this nucleotide may result in some conformational or post-translational alterations to the enzyme. These changes might affect in...
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