Article
A2 allele polymorphism of the CYP17 gene and prostate cancer risk in an iranian population.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Karimpur-Zahmatkesh Arezu, Farzaneh Farah, Pouresmaeili Farkhondeh, Hosseini Jalil, Azarghashb Eznollah, Yaghoobi Mohammad
Abstract excerpt
BACKGROUND: Studies have shown that alterations of steroid hormone metabolism, particularly involving testosterone, affect the risk of prostate cancer. Therefore, genetic variation in genes of enzymes which are involved could be of importance. The gene most interest is CYP17, whose enzyme product has an essential role in testosterone hormone synthesis. Some studies have indicated that the A2 allele polymorphism...
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