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Article

The role of CYP17A1 in prostate cancer development: structure, function, mechanism of action, genetic variations and its inhibition.

General physiology and biophysics - 1 Dec 2017

Kmeťová Sivoňová Monika, Jurečeková Jana, Tatarková Zuzana, Kaplán Peter, Lichardusová Lucia, Hatok Jozef

Abstract excerpt

Androgens play an important role during the development of both normal prostate epithelium and prostate cancer and variants of genes involved in androgen metabolism may be related to an increased risk of prostate disease. Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) is a key regulatory enzyme in the steroidogenic pathway; it catalyses both 17α-hydroxylase and 17,20-lyase activities and is essential for...

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PMID: 29372682
DOI: 10.4149/gpb_2017024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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