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Article

CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China.

International journal of cancer - 1 Nov 2003

Madigan M Patricia, Gao Yu-Tang, Deng Jie, Pfeiffer Ruth M, Chang Bao-Li, Zheng Siqun, Meyers Deborah A, Stanczyk Frank Z, Xu Jianfeng, Hsing Ann W

Abstract excerpt

Because androgens likely play a key role in prostate growth and prostate cancer development, variants of genes involved in androgen biosynthesis may be related to prostate cancer risk. The enzyme P450c17alpha, encoded by the CYP17 gene, catalyzes the conversion of progesterone and pregnenolone into precursors of potent androgens. In the 5' promoter region of the CYP17 gene, a T (A1 allele) to C substitution (A2...

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Identifiers

PMID: 12949806
DOI: 10.1002/ijc.11378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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