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Article

The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.

Journal of molecular biology - 15 Nov 2013

Rathore Anurag, Carpenter Michael A, Demir Özlem, Ikeda Terumasa, Li Ming, Shaban Nadine M, Law Emily K, Anokhin Dmitry, Brown William L, Amaro Rommie E, Harris Reuben S

Abstract excerpt

APOBEC3A and APOBEC3G are DNA cytosine deaminases with biological functions in foreign DNA and retrovirus restriction, respectively. APOBEC3A has an intrinsic preference for cytosine preceded by thymine (5'-TC) in single-stranded DNA substrates, whereas APOBEC3G prefers the target cytosine to be...

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Identifiers

PMID: 23938202
DOI: 10.1016/j.jmb.2013.07.040
PMCID: PMC3812309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23938202-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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