Article
Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations.
Molecular immunology - 1 May 2009
St Swierzko Anna, Cedzynski Maciej, Domzalska-Popadiuk Iwona, MacDonald Shirley L, Borkowska-Klos Monika, Atkinson Anne P M, Szala Agnieszka, Jopek Aleksandra, Jensenius Jens C, Kawakami Masaya, Szczapa Jerzy, Matsushita Misao, Szemraj Janusz, Turner Marc L, Kilpatrick David C
Abstract excerpt
One collectin (mannan-binding lectin, MBL) and three ficolins (M-ficolin/ficolin-1, L-ficolin/ficolin-2 and H-ficolin/ficolin-3) share the capability to activate complement via the lectin pathway. This property depends on the ability of these lectins to form complexes with MBL-associated serine proteases (MASPs), particularly MASP-2. We report the results of an investigation of cord blood MASP-2 concentrations in...
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