Article
Association of the FCN2 Gene Promoter Region Polymorphisms with Very Low Birthweight in Preterm Neonates.
International journal of molecular sciences - 5 Dec 2022
Szala-Poździej Agnieszka, Świerzko Anna S, Gajek Gabriela, Kufelnicka-Babout Maja, Chojnacka Karolina, Kobiela Paulina, Jarych Dariusz, Sobczuk Katarzyna, Mazela Jan, Domżalska-Popadiuk Iwona, Kalinka Jarosław, Sekine Hideharu, Matsushita Misao, Cedzyński Maciej
Abstract excerpt
Single nucleotide polymorphisms (SNPs) localised to the promoter region of the FCN2 gene are known to influence the concentration of ficolin-2 in human serum and therefore potentially have clinical associations. We investigated the relationships between SNPs at positions −986 (A > G), −602 (G > A), −64 (A > C) and −4 (A > G) and clinical complications in 501 preterms. Major alleles at positions −986 and −64 and...
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