Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates.

doi:10.1016/j.molimm.2008.07.025

Article

Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates.

Molecular immunology - 1 Feb 2009

Swierzko Anna St, Atkinson Anne P M, Cedzynski Maciej, Macdonald Shirley L, Szala Agnieszka, Domzalska-Popadiuk Iwona, Borkowska-Klos Monika, Jopek Aleksandra, Szczapa Jerzy, Matsushita Misao, Szemraj Janusz, Turner Marc L, Kilpatrick David C

Abstract excerpt

Ficolins and one collectin, mannan-binding lectin (MBL), are the only factors known to activate the lectin pathway (LP) of complement. There is considerable circumstantial evidence that MBL insufficiency can increase susceptibility to various infections and influence the course of several non-infectious diseases complicated by infections. Much less information is available concerning l-ficolin. We report the...

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Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates.

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