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Article

Epistatic interaction between genetic variants in susceptibility gene ETS1 correlates with IL-17 levels in SLE patients.

Annals of human genetics - 1 Jul 2013

Zhang Jing, Zhang Yan, Zhang Lu, Yang Jing, Ying Dingge, Zeng Shuai, Lee Tsz Leung, Lau Chak Sing, Chan Tak Mao, Leung Alexander Moon Ho, Mok Chi Chiu, Wong Sik Nin, Lee Ka Wing, Ho Marco Hok Kung, Lee Pamela Pui Wah, Chung Brian Hon-Yin, Chong Chun Yin, Wong Raymond Woon Sing, Mok Mo Yin, Wong Wilfred Hing Sang, Lau Yu Lung, Yang Wanling

Abstract excerpt

T-helper cells that produce IL-17 (Th17 cells) are a subset of CD4(+) T-cells with pathological roles in autoimmune diseases including systemic lupus erythematosus (SLE), and ETS1 is a negative regulator of Th17 cell differentiation. Our previous work on genome-wide association study (GWAS) identified two variants in the ETS1 gene (rs10893872 and rs1128334) as being associated with SLE. However, like many other...

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Share to Epistasis, Genetic
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Source

Identifiers

PMID: 23614478
DOI: 10.1111/ahg.12018

Genes

ETS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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