Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk.

doi:10.1186/s13075-020-02181-4

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Article

Synergistic activation of NF-κB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk.

Arthritis research & therapy - 25 Apr 2020

Kim Taehyeung, Bae Sang-Cheol, Kang Changwon

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this study to statistically and functionally characterize a gene-gene interaction (epistasis) recently documented to affect SLE risk. METHODS: Two single-nucleotide polymorphisms, rs2230926 in TNFAIP3...

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Identifiers

PMID: 32334614
DOI: 10.1186/s13075-020-02181-4
PMCID: PMC7183688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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