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Article

Gene-gene interactions of IRF5, STAT4, IKZF1 and ETS1 in systemic lupus erythematosus.

Tissue antigens - 1 Jun 2014

Dang J, Shan S, Li J, Zhao H, Xin Q, Liu Y, Bian X, Liu Q

Abstract excerpt

Interferon (IFN) activation signaling and T helper 17 (Th17)-cell/B-cell regulation play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). Several studies have provided convincing evidence that polymorphisms in IRF5, STAT4, IKZF1 and ETS1 from these pathways may be involved in SLE by affecting gene expression or epistasis. We analyzed the genetic interaction in known SLE susceptibility...

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Topics

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Share to Epistasis, Genetic
Share to Ikaros Transcription Factor
Share to Interferon Regulatory Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

Share to Proto-Oncogene Protein c-ets-1

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Source

Identifiers

PMID: 24697319
DOI: 10.1111/tan.12349

Genes

ETS1
IKZF1
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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