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Article

Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature.

Arthritis research & therapy - 4 Nov 2021

Qi Yuan-Yuan, Zhao Xin-Yu, Liu Xin-Ran, Wang Yan-Na, Zhai Ya-Ling, Zhang Xiao-Xue, Wang Xiao-Yang, Zhang Li-Jie, Zhao Ya-Fei, Cui Yan, Ning Xiang-Hui, Zhou Xu-Jie

Abstract excerpt

BACKGROUND: Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of variants located in the cytotoxic T lymphocyte-associated protein-4 (CTLA4)-inducible T cell co-stimulator (ICOS) intergenic region to SLE susceptibility. Our aim is to find a functional variant in...

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Identifiers

PMID: 34736521
DOI: 10.1186/s13075-021-02664-y
PMCID: PMC8567630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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