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Article

Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosus.

PloS one - 1 Jan 2012

Leng Rui-Xue, Wang Wei, Cen Han, Zhou Mo, Feng Chen-Chen, Zhu Yan, Yang Xiao-Ke, Yang Mei, Zhai Yu, Li Bao-Zhu, Wang Xiao-Song, Li Rui, Chen Gui-Mei, Chen Hong, Pan Hai-Feng, Ye Dong-Qing

Abstract excerpt

Several confirmed genetic susceptibility loci involved in the interferon signaling and Th17/B cell response for SLE in Chinese Han populations have been described. Available data also indicate that sex-specific genetic differences contribute to SLE susceptibility. The aim of this study was to test for gene-gene/gene-sex epistasis (interactions) in these known lupus susceptibility loci. Six single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

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Source

Open in PubMed Open full text

Identifiers

PMID: 23236436
DOI: 10.1371/journal.pone.0051090
PMCID: PMC3517573

Genes

ETS1
IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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