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Article

An aromatic residue switch in enhancer-dependent bacterial RNA polymerase controls transcription intermediate complex activity.

Nucleic acids research - 1 Jun 2013

Wiesler Simone C, Weinzierl Robert O J, Buck Martin

Abstract excerpt

The formation of the open promoter complex (RPo) in which the melted DNA containing the transcription start site is located at the RNA polymerase (RNAP) catalytic centre is an obligatory step in the transcription of DNA into RNA catalyzed by RNAP. In the RPo, an extensive network of interactions is established between DNA, RNAP and the σ-factor and the formation of functional RPo occurs via a series of...

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Identifiers

PMID: 23609536
DOI: 10.1093/nar/gkt271
PMCID: PMC3675486

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Source receipt: pubmed, retrieved 7 Sept 2026.

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