Article
rRNA promoter regulation by nonoptimal binding of sigma region 1.2: an additional recognition element for RNA polymerase.
Cell - 16 Jun 2006
Haugen Shanil P, Berkmen Melanie B, Ross Wilma, Gaal Tamas, Ward Christopher, Gourse Richard L
Abstract excerpt
Regulation of transcription initiation is generally attributable to activator/repressor proteins that bind to specific DNA sequences. However, regulators can also achieve specificity by binding directly to RNA polymerase (RNAP) and exploiting the kinetic variation intrinsic to different RNAP-promoter complexes. We report here a previously unknown interaction with Escherichia coli RNAP that defines an additional...
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