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Article

Stable DNA opening within open promoter complexes is mediated by the RNA polymerase beta'-jaw domain.

The Journal of biological chemistry - 28 Oct 2005

Wigneshweraraj Siva R, Burrows Patricia C, Severinov Konstantin, Buck Martin

Abstract excerpt

DNA opening for transcription-competent open promoter complex (OC) formation by the bacterial RNA polymerase (RNAP) relies upon a complex network of interactions between the structurally conserved and flexible modules of the catalytic beta and beta'-subunits, RNAP-associated sigma-subunit, and the DNA. Here, we show that one such module, the beta'-jaw, functions to stabilize the OC. In OCs formed by the major...

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Identifiers

PMID: 16123036
DOI: 10.1074/jbc.M506416200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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