Article
Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
Molecular psychiatry - 1 Jul 2013
Nho K, Corneveaux J J, Kim S, Lin H, Risacher S L, Shen L, Swaminathan S, Ramanan V K, Liu Y, Foroud T, Inlow M H, Siniard A L, Reiman R A, Aisen P S, Petersen R C, Green R C, Jack C R, Weiner M W, Baldwin C T, Lunetta K, Farrer L A, Furney S J, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, McDonald B C, Farlow M R, Ghetti B, Huentelman M J, Saykin A J
Abstract excerpt
Whole-exome sequencing of individuals with mild cognitive impairment, combined with genotype imputation, was used to identify coding variants other than the apolipoprotein E (APOE) ε4 allele associated with rate of hippocampal volume loss using an extreme trait design. Matched unrelated APOE ε3 homozygous male Caucasian participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were selected at the...
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