Article
Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
Molecular psychiatry - 1 Jul 2013
Nho K, Corneveaux J J, Kim S, Lin H, Risacher S L, Shen L, Swaminathan S, Ramanan V K, Liu Y, Foroud T, Inlow M H, Siniard A L, Reiman R A, Aisen P S, Petersen R C, Green R C, Jack C R, Weiner M W, Baldwin C T, Lunetta K, Farrer L A, Furney S J, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, McDonald B C, Farlow M R, Ghetti B, Huentelman M J, Saykin A J
Abstract excerpt
Whole-exome sequencing of individuals with mild cognitive impairment, combined with genotype imputation, was used to identify coding variants other than the apolipoprotein E (APOE) ε4 allele associated with rate of hippocampal volume loss using an extreme trait design. Matched unrelated APOE ε3 h...
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