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Article

A genome-wide scan for common variants affecting the rate of age-related cognitive decline.

Neurobiology of aging - 1 May 2012

De Jager Philip L, Shulman Joshua M, Chibnik Lori B, Keenan Brendan T, Raj Towfique, Wilson Robert S, Yu Lei, Leurgans Sue E, Tran Dong, Aubin Cristin, Anderson Christopher D, Biffi Alessandro, Corneveaux Jason J, Huentelman Matthew J, Rosand Jonathan, Daly Mark J, Myers Amanda J, Reiman Eric M, Bennett David A, Evans Denis A

Abstract excerpt

Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic conditions of aging, including neurodegenerative and vascular disease. Because common neuronal mechanisms may mediate the adaptation to diverse cerebral insults, we hypothesized that susceptibility for age-related cognitive decline may be due in part to a shared genetic network. We have therefore performed a genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22054870
DOI: 10.1016/j.neurobiolaging.2011.09.033
PMCID: PMC3307898

Genes

APOE
MTFR1

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