Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.

doi:10.1002/alz.12106

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Article

Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2020

Sherva Richard, Gross Alden, Mukherjee Shubhabrata, Koesterer Ryan, Amouyel Philippe, Bellenguez Celine, Dufouil Carole, Bennett David A, Chibnik Lori, Cruchaga Carlos, Del-Aguila Jorge, Farrer Lindsay A, Mayeux Richard, Munsie Leanne, Winslow Ashley, Newhouse Stephen, Saykin Andrew J, Kauwe John S K, Crane Paul K, Green Robert C

Abstract excerpt

INTRODUCTION: Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome-wide association study to examine rate of cognitive decline (ROD) in patients with AD. METHODS: We tested for interactions between genetic variants and time since diagnosis to predict the ROD of a composite cognitive score in 3946 AD cases and performed pathway analysis on the top genes....

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Identifiers

PMID: 32573913
DOI: 10.1002/alz.12106
PMCID: PMC7924136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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