Article

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

2020-04-27

Abstract excerpt

<h4>Summary</h4> Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal MRI da...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75e39b0e-afd8-5dfe-9f48-4d4bcf1fdb2a
DOI: 10.1101/2020.04.24.031138

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespanDOI 10.1101/2020.04.24.031138Read

Regional patterns of human cortex development correlate with underlying neurobiologySemantic proximity Read

Sex-Dependent Age Trajectories of Subcortical Brain Structures: Analysis of Large-Scale Percentile Models and Shape MorphometrySemantic proximity Read

The Interaction Effects of Age, APOE and Common Environmental Risk Factors on Human brain StructureSemantic proximity Read

The interaction effects of age, APOE and common environmental risk factors on human brain structure.Semantic proximity Read

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE ConsortiumSemantic proximity Read

Greater male than female variability in regional brain structure across the lifespanSemantic proximity Read

Greater male than female variability in regional brain structure across the lifespanSemantic proximity Read

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.Semantic proximity Read

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life StagesSemantic proximity Read

Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associationsSemantic proximity Read

Genetic architecture of brain age and its casual relations with brain and mental disordersSemantic proximity Read

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain agingSemantic proximity Read