Article
Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations.
Blood - 6 Jun 2013
Neumann Martin, Heesch Sandra, Schlee Cornelia, Schwartz Stefan, Gökbuget Nicola, Hoelzer Dieter, Konstandin Nikola P, Ksienzyk Bianka, Vosberg Sebastian, Graf Alexander, Krebs Stefan, Blum Helmut, Raff Thorsten, Brüggemann Monika, Hofmann Wolf-Karsten, Hecht Jochen, Bohlander Stefan K, Greif Philipp A, Baldus Claudia D
Abstract excerpt
Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a high-risk subgroup of T-lineage ALL characterized by specific stem cell and myeloid features. In adult ETP-ALL, no comprehensive studies on the genetic background have been performed to elucidate molecular lesions of this distinct subgroup. We performed whole-exome sequencing of 5 paired ETP-ALL samples. In addition to mutations in genes known...
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