Article
ETV6 mutations in early immature human T cell leukemias.
The Journal of experimental medicine - 19 Dec 2011
Van Vlierberghe Pieter, Ambesi-Impiombato Alberto, Perez-Garcia Arianne, Haydu J Erika, Rigo Isaura, Hadler Michael, Tosello Valeria, Della Gatta Giusy, Paietta Elisabeth, Racevskis Janis, Wiernik Peter H, Luger Selina M, Rowe Jacob M, Rue Montserrat, Ferrando Adolfo A
Abstract excerpt
Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for ~5-10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relationship between...
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