Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations

27 Jan 2012

Abstract excerpt

A subgroup of pediatric acute T-lymphoblastic leukemia (T-ALL) was characterized by a gene expression profile comparable to that of early T-cell precursors (ETPs) with a highly unfavorable outcome. We have investigated clinical and molecular characteristics of the ETP-ALL subgroup in adult T-ALL. As ETP-ALL represents a subgroup of early T-ALL we particularly focused on this cohort and identified 178 adult...

Topics

Join the communities discussing this publication.

Acute Lymphoblastic Leukemia research
Chronic Myeloid Leukemia Treatments
T-cell and Retrovirus Studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22829239
DOI: 10.1038/bcj.2011.49

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutationsPMID 22829239Read ↗

FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors.Semantic proximity Read ↗

Early T-Cell Precursor ALL and Beyond: Immature and Ambiguous Lineage T-ALL SubsetsSemantic proximity Read ↗

Inside the biology of early T-cell precursor acute lymphoblastic leukemia: the perfect trickSemantic proximity Read ↗

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients.Semantic proximity Read ↗

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.Semantic proximity Read ↗

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia.Semantic proximity Read ↗

Optimized outcome prediction of oncogenetic mutations in non-early T-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

The Profile of Immunophenotype and Genotype Aberrations in Subsets of Pediatric T-Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.Semantic proximity Read ↗

The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.Semantic proximity Read ↗

T-cell acute lymphoblastic leukaemia: subtype prevalence, clinical outcome, and emerging targeted treatmentsSemantic proximity Read ↗

NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.