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Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts.

Arthritis and rheumatism - 1 Dec 2013

Krabben A, Wilson A G, de Rooy D P C, Zhernakova A, Brouwer E, Lindqvist E, Saxne T, Stoeken G, van Nies J A B, Knevel R, Huizinga T W J, Toes R, Gregersen P K, van der Helm-van Mil A H M

Abstract excerpt

OBJECTIVE: The progression of joint destruction in rheumatoid arthritis (RA) is determined by genetic factors. Changes in IL4 and IL4R genes have been associated with RA severity, but this finding has not been replicated. This study was undertaken to investigate the association between IL4- and IL4R-tagging single-nucleotide polymorphisms (SNPs) and the progression rate of joint damage in RA in a multicohort...

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PMID: 23983153
DOI: 10.1002/art.38141

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