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Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial).

Circulation - 22 Mar 2016

Kullo Iftikhar J, Jouni Hayan, Austin Erin E, Brown Sherry-Ann, Kruisselbrink Teresa M, Isseh Iyad N, Haddad Raad A, Marroush Tariq S, Shameer Khader, Olson Janet E, Broeckel Ulrich, Green Robert C, Schaid Daniel J, Montori Victor M, Bailey Kent R

Abstract excerpt

BACKGROUND: Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS: Participants (n=203, 45-65 years of age, at intermediate risk for CHD, and not on statins) were randomly assigned to receive...

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Identifiers

PMID: 26915630
DOI: 10.1161/CIRCULATIONAHA.115.020109
PMCID: PMC4803581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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